Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes
نویسندگان
چکیده
منابع مشابه
Efficacy of antidepressants: similar but different.
Fountoulakis & Moller (2010) have re-analysed the Kirsch et al. (2008) meta-analysis of newer antidepressants and reached quite different conclusions to the original study. In particular they highlight that both venlafaxine and paroxetine exceed the NICE criteria for ‘clinical significance’ of 3 points on the Hamilton Rating Scale for Depression (HAMD) and that the Kirsch et al. analysis undere...
متن کاملUbiquitin-binding proteins: similar, but different.
Covalent modification of proteins with ubiquitin is a common regulatory mechanism in eukaryotic cells. Typically, ubiquitinated proteins are targeted for degradation by the 26 S proteasome. However, more recently the ubiquitin signal has also been connected with many other cell processes, including endocytosis, vesicle fusion, DNA repair and transcriptional silencing. Hence ubiquitination may b...
متن کاملActivating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCα
TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCgamma, we built a model of the catalytic region of TOR, from the FAT domain to near the end of the FATC domain. The model reveals that activating mutations in TOR, identified in yeast in a genetic selection for Rheb-independence, co...
متن کاملDeep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits.
Recent studies in patients with treatment-resistant depression have shown similar results with the use of deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG), ventral capsule/ventral striatum (VC/VS) and nucleus accumbens (Acb). As these brain regions are interconnected, one hypothesis is that by stimulating these targets one would just be influencing different relays in the s...
متن کاملTEG® and ROTEM® in trauma: similar test but different results?
INTRODUCTION Transfusion in trauma is often empiric or based on traditional lab tests. Viscoelastic tests such as thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) have been proposed as superior to traditional lab tests. Due to the similarities between the two tests, general opinion seems to consider them equivalent with interchangeable interpretations. However, it is not cl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2014
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2013.11.028